Podcast
A SkinDepth Convo
A SkinDepth Convo is a podcast for those looking to improve themselves from the inside out. In each episode, we explore the latest trends, breakthrough technologies, and get expert insights within the dynamic world of skincare and beauty. If you're looking to further your beauty, education and nurture your passion, you're in the right place. Renowned experts and hosts, Metaxia Dalikas and Francine Kagarakis aim to educate and inspire through their own experiences and are dedicated to enlightening and empowering enthusiasts and professionals in the realm of skincare and beauty.
Join the conversation and the fun with A SkinDepth Convo.
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Skin Depth Ep 65 – December 31, 2025 – Purely Clinical 2025 Recap
Purely Clinical is more than an event; it’s an experience where education meets innovation and the future of skincare takes shape. Over the past year, the Lira Clinical owners traveled across the globe delivering advanced education, protocol-driven learning, and exclusive first looks at upcoming innovations, straight to the treatment room. We’re recapping standout moments from the tour stops and unpacking what attendees truly gained, from interactive sessions and protocol development to testing prototypes and influencing product launches before they hit the market. And of course, we’re teasing what’s ahead, because Purely Clinical 2026 is already shaping up to be something special. Join expert hosts and Lira Clinical founders Metaxia Dalikas and Francine Kagarakis for an inside look at the experience that’s redefining clinical education.
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Skin Depth Ep 37 – May 19, 2023 – Combatting Skin Cancer? The Right Sunscreen Will Have You Covered!
As the most common type of cancer in the US, it’s estimated that 9,500 people are diagnosed with skin cancer everyday. Listen now as Metaxia and Francine discuss how to prevent it, detect it, and how to handle the damage. What sunscreen is right for YOUR skin? They share the key factors in why it’s important to choose the right sunscreen, and how to properly apply it all year round, rain or shine.
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Skin Depth Ep 38 – June 15, 2023 – Space, Skincare and Cyanobacteria
Discover the latest in new ingredients and skincare technology. Join Metaxia and Francine as they explore the remarkable potential of cyanobacteria and its profound impact on skincare with HelioBioSys Co-Founders, Rocco Mancinelli, Ph.D. and David Smernoff, Ph.D. Find out how these two scientists from the NASA Ames Research Center went from researching biofuel to entering the cosmetic industry with groundbreaking technology. HelioBioSys harvests and purifies ingredients from marine cyanobacteria to not only create clean and natural ingredients but also products that are environmentally safe. Listen now to learn the secrets of radiant, sustainable beauty and unlock the skincare benefits of cyanobacteria.
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Skin Depth Ep 39 – August 17, 2023 – How to Get the Most Out of Your Skin Care Trade Show Experience
How to Get the Most Out of Your Skin Care Trade Show Experience In this episode, Metaxia and Francine share tips & tricks on how to navigate the trade show floor for attendees and exhibitors. Listen now if you are interested in going beyond the basic exhibitor booth setup, growing your skincare business, building network connections, and finding out the latest technology in the industry.
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Skin Depth Ep 40 – September 22, 2023 – Start Healthy Aging Now
Did you know that aging starts in your mid-twenties? In today's episode, Metaxia & Francine discuss the positive aspects of growing older and ways to keep looking younger than our stated age. September is Healthy Aging Month, the perfect time to unlock the secrets of staying youthful at heart and keep your skin looking and feeling younger. How does your skincare routine in your 20s affect your skin when you are 40? How do we address aging skin over 50? Embrace your unique beauty at every stage of life. Listen now to see if you can catch any “Golden” references while learning tips to keep you looking your best, feeling your best, and living your best.
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Skin Depth Ep 41 – December 21, 2023 – Best Convos of 2023
Let’s revisit highlights of the best moments from the past year and get you ready for another season of A SkinDepth Convo. Happy Holidays from Lira Clinical!
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Skin Depth Ep 64 – December 17, 2025 – Best of 2025
From breakthrough launches to meaningful milestones, this episode of A SkinDepth Convo reflects on a year that shaped the future of clinical aesthetics. Join us as we revisit our defining moments, celebrating innovation, education, and the community that made it all possible. We look back on 2025, on a year of growth, innovation, and momentum, while setting intentions for what’s next. Tune in for a thoughtful recap of 2025 and a celebration of how far we’ve come together.
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Skin Depth Ep 65 – December 31, 2025 – Purely Clinical 2025 Recap
Purely Clinical is more than an event; it’s an experience where education meets innovation and the future of skincare takes shape. Over the past year, the Lira Clinical owners traveled across the globe delivering advanced education, protocol-driven learning, and exclusive first looks at upcoming innovations, straight to the treatment room. We’re recapping standout moments from the tour stops and unpacking what attendees truly gained, from interactive sessions and protocol development to testing prototypes and influencing product launches before they hit the market. And of course, we’re teasing what’s ahead, because Purely Clinical 2026 is already shaping up to be something special. Join expert hosts and Lira Clinical founders Metaxia Dalikas and Francine Kagarakis for an inside look at the experience that’s redefining clinical education.
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Skin Depth Ep 66 – April 13, 2026 – The Wellness Series: Virtual Fasting & The Magnificent Free 7 ft Dr. John Konstantin
In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis explore the powerful connection between internal health and skin health, revealing why true radiance starts from within. They are joined by special guest Dr. John Konstantin, who helps connect the dots between internal health and lasting, visible skin results. Together, they unpack how a holistic, inside-out approach is shaping the future of skincare and empowering both professionals and clients to think beyond the surface. Tune in to discover how aligning internal wellness with advanced skincare can transform not just your skin, but your overall health.
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Skin Depth Ep 67 – May 18, 2026 – A Revolution in PDRN ft The WildType Team
In this groundbreaking episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis are joined by the Wildtype team for an in-depth conversation on how biotechnology and regenerative science are transforming the future of skincare. If you’re curious about regenerative ingredients, cutting-edge skincare science, and the intersection of biotech and beauty, this is a conversation you won’t want to miss.
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Skin Depth Ep 68 – June 12, 2026 – A PDRN Revolution
The future of regenerative skincare is here. Join Metaxia, Francine, and Anna as they pull back the curtain on the launch of REGEN Line, Lira Clinical’s groundbreaking new collection designed to support skin recovery, renewal, and long-term skin health. In this special episode, they explore the science behind two buzzworthy innovations: PDRN and Wild Salmon Stem Cell-CM, and discuss how these advanced ingredients are transforming both professional treatments and home care. From concept to clinical application, get an exclusive look at the research, technology, and vision driving the next evolution of skincare. If you’ve been hearing the excitement around regenerative aesthetics, this is the episode you won’t want to miss.
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Skin Depth Ep 69 – August 4, 2026 – Signal, Deliver, Regenerate: The Latest Science in Skin Renewal ft The Wildtype Team
When new skincare technology emerges, questions naturally follow, and understanding the science is just as important as seeing the results. In this episode of A SkinDepth Convo, Lira Clinical founders Metaxia Dalikas and Francine Kagarakis speak with Dr. Aryé Elfenbein, Co-Founder of Wildtype, and Dr. Larry Weiss, Co-Founder and Managing Director of BiomeMimetics, LLC. Together, they reveal the science behind Marine Cellular Complex, also known as Wild Salmon Stem Cell Conditioned Media—the innovative regenerative technology featured in Lira Clinical’s new REGEN Line. What gives this Marine Cellular Complex four times greater regenerative power than PDRN alone? Tune in to uncover the research, including increased collagen and elastin production, reduced markers of inflammation, and powerful support for the skin’s natural renewal processes, and discover why this technology could represent a new frontier in professional skincare.
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Skip Depth Ep 43 – February 14, 2024 – Staying Current in the Evolving World of Medical Aesthetics
Explore the latest trends shaping the medical aesthetics industry. From the hottest topics on social media to sustainable packaging, join the Lira Clinical team as we dive into the transformative nature of skincare and how to stay current.
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Skip Depth Ep 51 – February 27, 2025 – Acne & Your Diet: What to Eat (and Avoid) for Clear Skin ft. Acne Nutritionist, Maria Marlowe
Can what you eat really make or break your skin? If you’re struggling with acne, a good skincare routine is key—but what’s on your plate might be just as important for achieving clear, healthy skin from the inside out! Metaxia and Francine are joined by nutritionist Maria Marlowe, who specializes in acne and is the author of "The Real Food Guide" and "Be Healthy Every Day." Listen now as Maria shares her expertise on the connection between our gut and skin, common acne-triggering mistakes, and her top dietary recommendations for achieving a clear complexion. Get ready to rethink your plate and clear your skin from the inside out!
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Skip Depth Ep 52 – March 19, 2025 – The Purely Clinical 2.0 Experience
On this episode of A SkinDepth Convo, Metaxia and Francine take you behind the scenes of the Purely Clinical Global Skin Affair Tour—sharing unforgettable moments, expert insights, and what’s in store for Purely Clinical 2.0! Get ready for the most anticipated skincare event of 2025, where professionals worldwide will dive into cutting-edge skin condition education and the latest breakthroughs in barrier-building science. 🎧 Tune in now and be the first to know what’s next in the future of skincare!
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Skip Depth Ep 53 – April 16, 2025 – Body Confidence
Get ready to glow from head to toe! On this episode of A SkinDepth Convo, Metaxia and Francine tackle body confidence beyond your face. Skincare isn’t just about your face—we’re talking self-care rituals, head-to-toe skin love, and the hottest trends in 2025. Tune in for tips, innovations, and all the inspiration to feel confident in your skin!
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Skip Depth Ep 54 – May 12, 2025 – Fifty, Fabulous, and Empowered ft. Kimyatta
On this episode of A SkinDepth Convo, we’re talking confidence, growth, and making 50 look fierce. Metaxia and Francine welcome the brilliant Kimyatta Albert, who’s celebrating her milestone birthday not just with a “50 and fabulous” party, but with an unwavering sense of purpose. Kimyatta, a renowned esthetician, mindset coach, and business mentor, dives into what it means to hit life’s big milestones with style and strength. She’ll reveal how to harness your inner resilience, radiate confidence, and build a life that aligns with your true purpose. Tune in for a powerful conversation about glowing from the inside out and thriving at every stage of life.
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Skip Depth Ep 55 – June 17, 2025 – Understanding Cosmetic Chemistry, Part One: Emulsions ft. Dr. Gabriella Baki
Get ready for Part One of a special two-part episode of A SkinDepth Convo! Part one dives into one of the most essential yet overlooked aspects of skincare science: Emulsions. Then, in part two, we’ll explore the chemistry behind sunscreen and SPFs. Joining Metaxia and Francine is a true expert in cosmetic science, Dr. Gabriella Baki. She’s an associate professor at the University of Toledo’s College of Pharmacy and Pharmaceutical Sciences and the Program Director of its groundbreaking Cosmetic Science and Formulation Design major. Dr. Baki teaches both undergraduate and online master’s students while leading research in topical ingredient delivery, sun protection, and the sensory experience of skincare products. Don’t miss this deep-dive into the science behind the products we use every day!
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Skip Depth Ep 56 – July 9, 2025 – Understanding Cosmetic Chemistry Part 2: Sunscreen, ft Dr. Gabriella Baki
In the second part of Understanding Cosmetic Chemistry of A SkinDepth Convo, Metaxia and Francine are joined once again by cosmetic chemist, Dr. Gabriella Baki, to breakdown the science behind one of the most essential skincare products: sunscreen. From understanding how SPF is formulated to exploring its critical importance for ALL Fitzpatrick skin types, this conversation dives deep into the science behind shielding your skin. We’ll explore the link between melanin and SPF, clear up common myths, and discuss why skin cancer rates are rising—even among those who think they don’t need sunscreen. This episode will help you rethink your approach to sun protection.
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Skip Depth Ep 57 – August 12, 2025 – Regenerative Esthetics ft. Dr. Chantal Lunderville
Get ready for an empowering discussion about women’s health, regenerative aesthetics, and building confidence from the inside out! In this episode, hosts Metaxia Dalikas and Francine Kagarakis are joined by the incredible Dr. Chantal Lunderville, a physician trained at UCLA and UCSF and Lipgloss & Aftershave Medical + Wellness Editor, who’s redefining aging with a bold, holistic approach to esthetics and wellness. Hear from Dr. C, founder of her own esthetic practice and host of the podcast “Spilling the Medical Tea”, as she shares insights on the connection between skin, hormones, and overall health. Plus, we’ll explore how spas are evolving into vital bridges between physicians and clients, and discuss the importance of combining traditional and holistic approaches to achieve true beauty and wellness. Don’t miss this conversation packed with invaluable advice and expertise!
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Skip Depth Ep 58 – September 10, 2025 – Mohs Surgery & Skin Cancer: Precision in Treatment with Dr. Mariam Mafee
In the latest episode of A SkinDepth Convo, hosts Metaxia, Francine, and Anna explore one of dermatology's most critical topics: skin cancer treatment through Mohs surgery. Did you know success rates for Mohs Surgery are over 99% for basal cell carcinoma? Joining us is Dr. Mariam Mafee MD, a board-certified dermatologist and Mohs surgeon at Rush University Medical Center (rush.edu) in Chicago. Known for her surgical expertise and compassionate patient care, Dr. Mariam Mafee discusses the intricacies of Mohs surgery, including post-surgery care, preparation for surgery, and why it is such a highly effective procedure in treating skin cancer. The discussion emphasizes the importance of patient education, the high success rates of Mohs surgery, and the need for awareness regarding skin health. Dr. Mafee also shares practical advice for patients, including the use of sunscreen, how long to wait to do a peel after surgery, and what other measures to take to protect your skin. Whether you're a healthcare professional, someone facing a skin cancer diagnosis, or simply want to better protect your skin, this episode offers valuable insights that could save lives.
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Skip Depth Ep 59 – September 22, 2025 – Spice Up for Skincare with Pumpkin Peels with The Lira Clinical Education Team
On the new episode of A SkinDepth Convo, we're diving deep into our new favorite seasonal ingredient: Pumpkin! When you think of pumpkin, your mind might go straight to lattes, pies, and fall decorations. But did you know it's also a powerhouse ingredient in skincare? Packed with vitamins and minerals, pumpkin brightens, hydrates, and repairs the skin, making it a true multitasking marvel. It's more than just a seasonal craze; it's a skincare game-changer. Join our hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis as they're joined by the Lira Clinical Education Team, Tiffany Fraedrich, George Gallegos, and Lu Ramos. Together, they get spicy discussing the new Pumpkin Plus Smart Peel™ from Lira Clinical and share fascinating facts about the pumpkin spice phenomenon, which has grown into an $800 million industry. Listen now to uncover the powerful benefits of pumpkin and learn how a simple marketing idea from Starbucks in 2003 evolved into a global sensation.
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Skip Depth Ep 60 – October 13, 2025 – Beauty Down Under: Skincare in Oceania ft. Lira Clinical ANZ Team - Kristen & Jo-Ann
Join us for an exciting episode as we explore the beauty and skincare landscape down under! We're welcoming special guests from Lira Clinical's Australia and New Zealand distribution teams - Kristen Schultz and Jo-Ann Slecht - along with Lira Clinical founders Metaxia Dalikas and Francine Kagarakis, plus owner Brenda Cumming. Discover the top skin conditions affecting the Oceania region and learn about the treatments and products making a real impact for clients. We'll also take you behind the scenes of the Global Skin Affair tour with exclusive highlights from the event. As a bonus, our local experts will share insider travel tips and hidden gems you won't find in any guidebook. And yes, we'll even get the scoop on Vegemite and Kangaroo DNA!
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Skip Depth Ep 61 – October 20, 2025 – Metaxia's Journey - Strength, Resilience & Skincare Through Breast Cancer
This October, in honor of Breast Cancer Awareness Month, we're sharing a deeply personal and inspiring story from Lira Clinical Co-Founder Metaxia Dalikas. As a breast cancer survivor, Metaxia opens up about her journey of courage, faith, and resilience, both in her personal battle and in her leadership of a global skincare company. In this powerful episode, Metaxia discusses her diagnosis and treatment experience, the challenges of balancing her health while running a business, and the incredible support she received from her family and Lira Clinical co-owners. She also shares expert advice on caring for your skin before, during, and after cancer treatments. Joining the conversation is fellow Lira Clinical founder and host Francine Kagarakis, who stood by Metaxia's side throughout her entire journey. Together, they offer hope, practical guidance, and inspiration for anyone facing similar challenges.
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Skip Depth Ep 62 – October 28, 2025 – Spooky Skin Care Stories
Things are getting spooky at A SkinDepth Convo! Hosts Anna Kagarakis, Metaxia Dalikas, and Francine Kagarakis are joined by the rest of the fabulous founders of Lira Clinical, Brenda Cumming, and Anna Konstantin, for a Halloween special you don’t want to miss. From real-life treatment room scares to lessons learned the hard way, these skincare pros share chilling (and hilarious) stories that remind us why education, safety, and the right products are no trick; they’re the ultimate treat. So grab your pumpkin spice latte, light that candle, and tune in… if you dare!
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Skip Depth Ep 63 – November 25, 2025 – Inclusive Skincare ft. SYNRG Owner, Gerline Jean-Louis
In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis dive into the beauty and complexity of treating diverse skin tones. Skincare is never one-size-fits-all, and understanding the needs of every background, heritage, and Fitzpatrick type is essential for truly inclusive care. Joined by Licensed Esthetician Gerline Jean-Louis, owner of SYNRG and a renowned practitioner specializing in higher Fitzpatrick skin types, Gerline shares her passion for education and empowerment, and valuable insight into what makes deeper skin tones unique, the misconceptions that persist in the industry, and the most common challenges her clients face. Tune in for an inspiring, knowledge-packed conversation that celebrates diversity in skin health.
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Skin Depth Ep 46 – July 5, 2024 – The ABC’s of LED Light Therapy
Listen now as Lira Clinical Owners, Francine Kagarakis and Metaxia Delikas, and Richard Maher, LE explore the science and benefits of LED light treatments for skin health. Discover how this innovative technology can enhance your skincare routine and achieve radiant results.
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Skip Depth Ep 49 – November 14, 2024 – Expanding SMART PEELS™
When it comes to peels, the first thought that comes to mind is corrective skincare. Traditional peeling involved skin inflammation, longer recovery times, and only for specific skin types and conditions. We’ve come a long way from that. Metaxia and Francine get together again, exploring the latest advancements in skincare technology as Lira Clinical continues to innovate new peels for brighter, healthier, and younger-looking skin. Listen now and learn the science, innovation, and passion behind Lira Clinical’s new SMART PEELS™: Exo Mandelic, Exo Retinoid, and Shikimic Plus.
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Skip Depth Ep 50 – December 31, 2024 – Best of 2024
2024 has been a year of growth in the skincare and beauty industry. Lira Clinical has launched the latest technology in delivery with barrier protection, EXO-tech™, added a breakthrough refinement eye crème to the PRO Line, expanded the SMART PEELS™ collection, connected with new friends nationally and internationally, and now Lira Clinical is expanding their corporate office! Join Metaxia Dalikas and Francine Kagarakis to look at some of the best moments of 2024 and review some of the forecasted trends to see if they came to fruition.
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Skin Depth Ep 48 – October 4, 2024 – Peel Appeal
In this episode of A SkinDepth Convo, we are peeling back the layers of clinical skincare. Peels are a major cornerstone in professional and clinical skincare, offering purely transformative results for different skin conditions. Listen now as Metaxia and Francine break down everything you need to know about peels and answer questions such as “Which peel is right for you or your clients?” “Why is it essential for skin health?” and “What makes it so special?”
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Skin Depth Ep 45 – June 5, 2024 – Breaking the Skin Barrier: Men’s Roles in Modern Skincare
Skin Depth Convo hosts and Lira Clinical owners Metaxia and Francine are joined by guests Michael Moore and George Gallegos to discuss finding support and empowerment as men in the skincare industry. Men are carving out their space long dominated by women. Discuss the shift of an increased presence of men in skincare.
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Skin Depth Ep 18 – September 17, 2021 – Summer Recover, Fall Renew
In our new podcast season of A SkinDepth Convo, Anna Kagarakis is joined by Lira Clinical Founders, Metaxia, Francine, Brenda, and Anna as they reminisce about their eventful summer trip to Greece. Listen now as they discuss recovering from the summer, preparing for the fall (Peel) season, and of course, Brenda’s Greek food experiences!
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Skin Depth Ep 42 – February 7, 2024 – Upcoming Trends of 2024
Let’s kick off 2024 by reviewing previous and upcoming trends. Lira Clinical owners, Francine and Metaxia, are joined by Lipgloss + Aftershave’s Barry Eichner and Jenni Nagle, to discuss what the year has in store.
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Skin Depth Ep 44 – April 23, 2024 – Purely Global and Travel Highlights
Explore the landscape of skin and beauty in Europe as hosts Metaxia and Francine delve into the latest trends shaping the industry. Lira Clinical’s recent international adventure offers insights into its transformative impact on beauty practices worldwide.
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Skip Depth Ep 47 – August 28, 2024 – Eye Love Exosomes! A Game Changer in Skin Care
Exosome technology is a hot topic in the skincare industry. The skin in the eye area is thinner and delicate, making it more prone to aging. Exosome technology allows for the delivery of proper ingredients to repair and maintain the health of the skin and Lira Clinical has developed a new eye cream that incorporates exosomes and addresses specific concerns around the eyes. Find out more about the PRO Refining Eye Crème and how Exosome Technology is advancing skincare.
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